Mesothelioma is a constellation of the mesothelial cells of the body. These cells are launch on the out layers of tissue that bloodline your intramural organs (the mesothelial application)
These linings better your organs to be able to propose as requisite within the embody. This form of asbestos cancer is unremarkably only launch in those that feature been exposed to asbestos. Asbestos was misused in galore industries in the foregone and is a highly cancerous idea. Puffing in the rubbish of asbestos can pass to any of the some types and forms of mesothelioma regularise some period after exposure.
The typewrite of mesothelioma is restricted according to the room typewrite of the malignancy, as advantageously as the location in which the human is initiate. If you find a diagnosis of mesothelioma, it is central to inform yourself with pandemic noesis near the disease as easily as with as often entropy as realizable regarding your particular identification. This module exploit in lettered what to expect and aid you in making decisions roughly your direction along the way
There are terzetto important types of mesothelioma saved with this designation that refer to the cell typewrite of the malignance found within the embody. These are epitheliod, sarcomatiod and mixed/biphasic. Epithelial mesothelioma (epithelioid) is the most unwashed and is open in 50-70 proportion of cases, which effectuation that quintuplet to heptad cases out of 10 are constitute to acquire this represent of mesothelioma. This is when the somebody has originated in the epithelial cells within the tissues surrounding the intimate meat.
Sarcomatous mesothelioma (sarcomatoid) is when cancerous tumors develop in the sinewy tissues or membranes of the mesothelial application. This write is saved in 7-20 pct of cases. This effectuation that fair seven to banknote patients within one cardinal leave be open to hit this typewrite.
Tuesday, August 31, 2010
Mesothelioma Surgey : Pneumonectomy
Mesothelioma is a extraordinary typewrite of cancer that develops in the mesothelium, the facing that surrounds and protects the embody's internal organs.
Presently, exclusive two types of potentially "healthful" surgeries exist to affect pleural mesothelioma, pleurectomy and extra pleural pneumonectomy. These two surgeries do not e'er aid mesothelioma, but can vanish the volume of the constellation cells, which in move helps to restrain the disease and growth a uncomplaining's history outlook. Extrapleural pneumonectomy is a author dangerous, aggressive, and terrible surgery than pleurectomy, but it also provides large potential for the outcome of the forbearing
Nearly Extrapleural Pneumonectomy
Extrapleural pneumonectomy involves the remotion of the whole pathologic lung, the pleural application of the bureau protect, the musculature, and the pleural lining of the bosom. Redundant pleural pneumonectomy is advised a grave computation, it is oftentimes dictated as a surgery of finally utilise. It is exclusive performed on patients who are in the former stages of soul; that is, before the house spreads to the lymph nodes and before it invades close tissues and organs. This allows the swell of the individual cells to be surgically distant
Surgery candidates demand to be in relatively suitable wellbeing, with just lung and pump purpose, because remotion of an whole lung testament increment the vexation on both the intuition and the remaining lung. Surgery candidates also essential to be knockout and ruddy enough to withstand the demands of star surgery and the alterative it gift require.
Benefits and Risks
Presently, exclusive two types of potentially "healthful" surgeries exist to affect pleural mesothelioma, pleurectomy and extra pleural pneumonectomy. These two surgeries do not e'er aid mesothelioma, but can vanish the volume of the constellation cells, which in move helps to restrain the disease and growth a uncomplaining's history outlook. Extrapleural pneumonectomy is a author dangerous, aggressive, and terrible surgery than pleurectomy, but it also provides large potential for the outcome of the forbearing
Nearly Extrapleural Pneumonectomy
Extrapleural pneumonectomy involves the remotion of the whole pathologic lung, the pleural application of the bureau protect, the musculature, and the pleural lining of the bosom. Redundant pleural pneumonectomy is advised a grave computation, it is oftentimes dictated as a surgery of finally utilise. It is exclusive performed on patients who are in the former stages of soul; that is, before the house spreads to the lymph nodes and before it invades close tissues and organs. This allows the swell of the individual cells to be surgically distant
Surgery candidates demand to be in relatively suitable wellbeing, with just lung and pump purpose, because remotion of an whole lung testament increment the vexation on both the intuition and the remaining lung. Surgery candidates also essential to be knockout and ruddy enough to withstand the demands of star surgery and the alterative it gift require.
Benefits and Risks
Women and Mesothelioma
A comment of the disease mesothelioma normally conjures up images of men excavation in shipyards or toiling in vermiculite mines in dwarfish towns throughout the U.S. Time it's avowedly, notwithstanding, that men are the most spectacular victims of mesothelioma and separate asbestos-related diseases, women are not immune from nonindustrial them.
As a entity of fact, cases of women with mesothelioma are on the increase as doctors and others address that the person sex is highly temptable to the disease, mostly through old danger; that is, exposure to a kindred member who worked with the ototoxic pigment on a regular assumption. Yet, secondhand danger is not the exclusive way in which women can modify much diseases
Spontaneous Danger to Asbestos
Throughout chronicle, in fated countries and cultures, exposure to asbestos occurred finished shared household tasks. For ideal, women in individual Sea countries, equal Turkey and Greece, oft oversaw the extend of "whitewashing" the home.
To those who active in modernistic times, the quantity whitewashing commonly refers to applying a cover of white blusher. Historically, nonetheless, whitewashing in these countries referred to the writ of using architect (asbestos-containing) alter to cover a sanctuary. It was also commonly victimized as plastering touchable for both inward and outside stucco. (Specified asbestos-laced bemire is naturally occurring in many of these areas.) The harmful pigment was also victimised on roofs for insularity and bar of installation leakage. Women (and others) were unclothed to dust emanating from the walls and the act of "sweeping" the area with a broom caused writer harmful fibers to travel. Alarmingly, the hot asbestos begrime was also sometimes victimized in approximate in these regions pretence an extremely overflowing grade of fresh asbestos exposure among women and umteen individuals are plant extant in and caring for homes where asbestos is ubiquitous.
As a entity of fact, cases of women with mesothelioma are on the increase as doctors and others address that the person sex is highly temptable to the disease, mostly through old danger; that is, exposure to a kindred member who worked with the ototoxic pigment on a regular assumption. Yet, secondhand danger is not the exclusive way in which women can modify much diseases
Spontaneous Danger to Asbestos
Throughout chronicle, in fated countries and cultures, exposure to asbestos occurred finished shared household tasks. For ideal, women in individual Sea countries, equal Turkey and Greece, oft oversaw the extend of "whitewashing" the home.
To those who active in modernistic times, the quantity whitewashing commonly refers to applying a cover of white blusher. Historically, nonetheless, whitewashing in these countries referred to the writ of using architect (asbestos-containing) alter to cover a sanctuary. It was also commonly victimized as plastering touchable for both inward and outside stucco. (Specified asbestos-laced bemire is naturally occurring in many of these areas.) The harmful pigment was also victimised on roofs for insularity and bar of installation leakage. Women (and others) were unclothed to dust emanating from the walls and the act of "sweeping" the area with a broom caused writer harmful fibers to travel. Alarmingly, the hot asbestos begrime was also sometimes victimized in approximate in these regions pretence an extremely overflowing grade of fresh asbestos exposure among women and umteen individuals are plant extant in and caring for homes where asbestos is ubiquitous.
Friday, August 20, 2010
Multimodal Treatment of Mesothelioma
For mesothelioma, many ways of treatment were performed by combining various methods. The most successful of these ways is “triple therapy” combination of surgical, chemotherapy and radiotherapy. In this way of treatment, the most significant element is to diagnose the disease in its early stage. Particularly, the method combination of high dose radiotherapy and chemotherapy with surgical has been most successful way of treatment for recovering patients.
An operation called as extrapleural pneumonectomy is performed in order to completely remove the tumor. Lining of the lung and entire lung affected in chest cavity (or thoracic cavity) and with diaphragm muscle and lung of the heart which touched with the lining of the lung are removed. In the last decade, reliability of operation has increased and risk of death (or mortality) after operation has dropped below 4% from about 10%. Considering that risk of death after open-heart surgery is 1-2%, the rate above-mentioned is quite high. By the end of the treatment, life expectancy of patients treated in USA increased above 2 years and it was seen a long lifetime period in a certain part of patients. In a study carried out in collaboration with Marmara University and Osmangazi University in Turkey, 4 year disease-free survival was observed in patients treated by the following protocol.
Triple therapy takes a total of six months. At first the operation is performed and after a month radiotherapy begins, which will take 2 months. After the radiotherapy, the patient rest for a month and chemotherapy is performed for 2 months. Completing all three treatment periods is essential to ensure adequate achievement against the disease.
An operation called as extrapleural pneumonectomy is performed in order to completely remove the tumor. Lining of the lung and entire lung affected in chest cavity (or thoracic cavity) and with diaphragm muscle and lung of the heart which touched with the lining of the lung are removed. In the last decade, reliability of operation has increased and risk of death (or mortality) after operation has dropped below 4% from about 10%. Considering that risk of death after open-heart surgery is 1-2%, the rate above-mentioned is quite high. By the end of the treatment, life expectancy of patients treated in USA increased above 2 years and it was seen a long lifetime period in a certain part of patients. In a study carried out in collaboration with Marmara University and Osmangazi University in Turkey, 4 year disease-free survival was observed in patients treated by the following protocol.
Triple therapy takes a total of six months. At first the operation is performed and after a month radiotherapy begins, which will take 2 months. After the radiotherapy, the patient rest for a month and chemotherapy is performed for 2 months. Completing all three treatment periods is essential to ensure adequate achievement against the disease.
Tuesday, August 17, 2010
Mesothelioma in Turkey - 2
It is declared that a virus named as SV can be connected to development of mesothelioma in studies carried out in recent years.
What are symptoms and findings of mesothelioma?
Because of the fact that disease mostly causes the pleurisy which is accumulation of fluid, generally first symptoms are back, chest and side pains. At first the pain while breathing is stinging character, but gradually intensity of pain increases and gains continuity. As a consequence of increasing fluid quantity accumulating in pleural cavity, patient has shortness of breath. Apart from this; there can also be symptoms such as cough, rarely clubbing and in relation to prevalence of the disease abdominal distention and abdominal pain.
Diagnostic approach in mesothelioma?
In examination of patient saw the doctor with above-mentioned complaints, it is determined that breath sounds decreased on the diseased side and generally the diseased side of chest was slightly reduced in proportion to the healthy side of chest. And the shoulder is lower on diseased side. In standard chest radiography and computed tomographic examination, it is seen that fluid accumulated in pleural cavity and lung membrane was thicken to wrap the lung such as an armor.
Some of fluid is examined by taken from patient determined the fluid in his/her pleural cavity by using radiological methods. Diagnosis of mesothelioma can be made in rare cases as a consequence of determined tumor cells in the fluid. But usually a piece of tissue is needed for definitive diagnosis. Biopsy can be performed by methods such as closed pleural biopsy, open pleural biopsy or thoracoscopic biopsy.(see pleurisy)
Treatment
Following the diagnosis of mesothelioma made by examination of biopsy specimen, treatment planning should be made. There are three types of mesothelioma – epithelial, sarcomatous(or sarcomatoid) and mixed(or biphasic). While chemotherapy and radiotherapy are performed in sarcomatous and mixed types mesothelioma, on the other hand options such as metastasis to opposite lung or other distant tissue and organs or else surgical treatment are available in epithelial type mesothelioma. Chemotherapy and radiotherapy should also be performed in the patient after the surgical intervention.
What are symptoms and findings of mesothelioma?
Because of the fact that disease mostly causes the pleurisy which is accumulation of fluid, generally first symptoms are back, chest and side pains. At first the pain while breathing is stinging character, but gradually intensity of pain increases and gains continuity. As a consequence of increasing fluid quantity accumulating in pleural cavity, patient has shortness of breath. Apart from this; there can also be symptoms such as cough, rarely clubbing and in relation to prevalence of the disease abdominal distention and abdominal pain.
Diagnostic approach in mesothelioma?
In examination of patient saw the doctor with above-mentioned complaints, it is determined that breath sounds decreased on the diseased side and generally the diseased side of chest was slightly reduced in proportion to the healthy side of chest. And the shoulder is lower on diseased side. In standard chest radiography and computed tomographic examination, it is seen that fluid accumulated in pleural cavity and lung membrane was thicken to wrap the lung such as an armor.
Some of fluid is examined by taken from patient determined the fluid in his/her pleural cavity by using radiological methods. Diagnosis of mesothelioma can be made in rare cases as a consequence of determined tumor cells in the fluid. But usually a piece of tissue is needed for definitive diagnosis. Biopsy can be performed by methods such as closed pleural biopsy, open pleural biopsy or thoracoscopic biopsy.(see pleurisy)
Treatment
Following the diagnosis of mesothelioma made by examination of biopsy specimen, treatment planning should be made. There are three types of mesothelioma – epithelial, sarcomatous(or sarcomatoid) and mixed(or biphasic). While chemotherapy and radiotherapy are performed in sarcomatous and mixed types mesothelioma, on the other hand options such as metastasis to opposite lung or other distant tissue and organs or else surgical treatment are available in epithelial type mesothelioma. Chemotherapy and radiotherapy should also be performed in the patient after the surgical intervention.
Mesothelioma in Turkey - 1
Although mesothelimoa included in rare tumors is frequently seen in our country in recent years, it is a malignant tumor taken origin from membranes that cover lung, heart and abdomen respectively called as pleura, pericardium, peritoneum. This tumor that generally emerges depending on asbestos exposure is mostly seen on pleura (lung membrane).
The most significant known risk factor for mesothelimoa is asbestos exposure. Asbestos, defined as mineral with fibrous structure, can be widely used in many industrial sectors. For example; it is known that asbestos is used in ship building and industrial sectors that produce brake lining systems, heat insulation materials and insulating materials. If adequate protection measures are not taken in workplace in which asbestos is used, the airborne fibrous particles enter the lung through respiration and pass from there to lung membrane, thus particles cause the mesothelimoa. Asbestos is significant risk factor in the development of lung cancer apart from mesothelimoa. Also it is a risk factor for some non cancer diseases called as benign asbestos that cause the pleurisy or interstitial lung disease.
As a consequence of researches carried out in Central Anatolia Region of Turkey, Prof. Dr. İzzettin Barış determined that some minerals (such as erionite) in soil also cause the mesothelimoa such as asbestos. Soil that contains these minerals and called as white soil (beyaz toprak) apply the wall of houses as plaster and paint material and so mesothelimoa is mostly seen disease in these regions.
To be continued
The most significant known risk factor for mesothelimoa is asbestos exposure. Asbestos, defined as mineral with fibrous structure, can be widely used in many industrial sectors. For example; it is known that asbestos is used in ship building and industrial sectors that produce brake lining systems, heat insulation materials and insulating materials. If adequate protection measures are not taken in workplace in which asbestos is used, the airborne fibrous particles enter the lung through respiration and pass from there to lung membrane, thus particles cause the mesothelimoa. Asbestos is significant risk factor in the development of lung cancer apart from mesothelimoa. Also it is a risk factor for some non cancer diseases called as benign asbestos that cause the pleurisy or interstitial lung disease.
As a consequence of researches carried out in Central Anatolia Region of Turkey, Prof. Dr. İzzettin Barış determined that some minerals (such as erionite) in soil also cause the mesothelimoa such as asbestos. Soil that contains these minerals and called as white soil (beyaz toprak) apply the wall of houses as plaster and paint material and so mesothelimoa is mostly seen disease in these regions.
To be continued
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